Our lab focuses on understanding the molecular mechanisms underlying embryonic stem (ES) cell self-renewal and differentiation. ES cells are remarkable cell lines, derived from the inner cell mass of pre-implantation embryos, that can grow indefinitely in culture. When an ES cell divides, it can either produce identical copies of itself (self-renewal) or other more specialized cell types (differentiation), such as neurons. Understanding how an ES cell makes this choice between self-renewal and differentiation is the central challenge in stem cell research.
- Broad Innovation Award winners work to develop cancer immunotherapy December 13, 2017
- Subtle cues can dictate the fate of stem cells December 4, 2017
- The protein TAZ sends “mixed signals” to stem cells August 24, 2017