University of Southern California

Ying Lab

USC Stem Cell

Generation of transgenic rats using embryonic stem cells

Conditional and inducible rat (Photo by Cristy Lytal)

Conditional and inducible rat (Photo by Cristy Lytal)

We are one of the first labs that derived authentic pluripotent embryonic stem (ES) cells from rats.

Using embryonic stem cell-based technology, we produced the world’s first knockout rats, which ranked among Science magazine’s “Top 10 Breakthroughs of 2010. Since then, we have succeeded in generating knock-in rats as well as conditional and inducible rats.

These animals allow scientists to model and study a wide range of genetic diseases that also occur in humans.